Isaac Newton writes in Mathematical Principles of Natural Philosophy Book Three System of the World General Scholium:
‘.... He is eternal and infinite, omnipotent and omniscient; that is his duration reaches from eternity to eternity; his presence from infinity to infinity; he governs all things and knows all things that are or can be done. He is not eternity and infinity, but eternal and infinite; he is not duration or space but he endures and present. He endures forever, and is everywhere present; and, by existing always and everywhere, he constitutes duration and space. ... He is omnipresent not virtually only, but also substantially; for virtue cannot subsist without substance. In him are all things contained and moved; yet neither affects the other: God suffers nothing from the motion of bodies; bodies find no resistance from the omnipresence of God. ... he exists always and everywhere. Whence also he is similar, ...; but in a manner not at all human, in a manner not at all corporeal, in a manner utterly unknown to us. ... He is utterly void of all body and bodily figure, and can therefore neither be seen, nor heard, nor touched; ...We have ideas of his attributes, but what the real substance of anything is we know not. In bodies, we see only their figures and colors, we hear only the sounds, we touch only their outward surfaces, we smell only the smells, and taste the savors; but their inward substances are not to be known either by our senses, or by any reflex act of our minds ... ; for all our notions of God are taken from the ways of mankind by certain similitude, which, though not perfect, has some likeness, however. And thus much concerning God; to discourse of whom from the appearances of things, does certainly belong to natural philosophy.
... hitherto I have not been able to discover the cause of those properties of gravity from phenomena, and I frame no hypotheses; for whatever is not deduced from the phenomena is to be called an hypothesis; and hypotheses, whether metaphysical or physical, whether of occult qualities or mechanical, have no place in experimental philosophy. In this philosophy particular propositions are inferred from the phenomena, and afterwards rendered general by induction...’

 If one reads the above, understanding that God is a human concept and tries to catch the meaning of this concept - following the above explanation -, he has to conclude that it is the existence. Newton also made the determination that it is the real substance of anything, what he is talking about. Now this only existing substance is always and everywhere and is similar, suffers nothing from the motion of bodies, eternal and infinite, endures and present, constitutes duration and space.
 Is there a possibility to incorporate such a substance into our reflection of reality? What if the separated from any form, pure existence is represented by something (rather no-thing) in the nature, could we describe it? Practically Newton gave the answer to it: eternal and infinite. Ever existing elements with infinitely high speed can penetrate any place for an infinitely small duration and if these elements collide with an other similar element they constitute an event and a location. This event is followed by nothing, which followed by an other event (constituting duration) and if these chains of events (and separators between them) are preserved (constituting space), we may even know about them, these could construct the things. The only assumption one has to make that the colliding elements suffer a direction change in the collision, and we get a possibility of self-organization, so the chains of events could preserve themselves.
 The following from this understanding reflection of reality, the cause of gravity and the meaning of our space, time and mass concepts, meaning and differences of the fields and the elements of interactions through the fields, structure of the nuclides of atoms (which fits very well to the observed abundances of isotopes) you could see here.

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